Analgesic effect of intrathecal menthol in a rat model of neuropathic pain
The transient receptor potential(TRP) channel family is one of the largest families of ion channels widely distributed on central nervous system as well as peripheral nervous system. Members of TRP family are involved in a wide range of physiological and pathophysiological processes including temperature sensation,taste, pain, growth regulation and calcium balance regulation.Transient receptor potential melastatin 8(TRPM8),which belongs to TRP channel family,plays a crucial role in cold sensation in mammals”1”.Recent study indicates that mice deficient in TRPM8 channel exhibits attenuated sensitivity to cold stimuli and coolant compounds such as menthol and icilin”2”. The purpose of this research is to investigate the effect of intrathecal(IT) menthol on hyperalgesia of rats with chronic neuropathic pain,and try to elucidate the role of TRPM8 channel in the mechanism of pain hypersensitivity associated with neuropathic states.
SU Lin
Department of Anesthesiology,Tianjin Medical University General Hospital
国内会议
天津
英文
261-266
2009-12-05（万方平台首次上网日期，不代表论文的发表时间）