Molecular mechanisms of Osteoblast-specific transcription factor Osx effect on bone formation
Bone formation is a developmental process involving the differentiation of mcsenchymal stem cells to osteoblasls. Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation and bone formation. Osx knock-out mice lack bone completely, and cartilage is normal. El8.5 Osx-null calvaria showed greater BrdU incorporation than wild-type calvaria, and Osx overexpression inhibited cell growth, suggesting that Osx inhibits osteoblast proliferation. To identify downstream targets of Osx to explore molecular mechanism of Osx effect on osteoblast differentiation and proliferation, Microarray was performed to compare gene profiles between Osx KO and WT calvaria cells at E18.5.
Chi Zhang
Bone Research Laboratory. Texas Scottish Rile Hospital for Children University of Texas Southwestern Medical Center, Dallas, Texas, USA
国内会议
北京
英文
96-97
2012-04-19（万方平台首次上网日期，不代表论文的发表时间）