Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.

摘要：

Natural products inhibiting fatty acid synthase (FAS) are appearing as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Nephelium lappaceum L. resulted in the isolation of ten compounds (1-10) mainly including flavonoids and oleane-type triterpene oligoglycosides, in which all of the compounds were isolated from this plant for the first time. Additionally, compounds 8 and 9 were new hederagenin derivatives and were elucidated as hederagenin 3-O-(2,3-di-O-acetyl-a-L-

关键词： Nephelium lappaceum L. Oleane-type triterpene oligoglycosides Fatty acid synthase (FAS) FAS inhibitors

作者: You-Xing Zhao Qing-Yun Ma Wen-Juan Liang He-Zhong Jiang Xiao-Feng Ma

作者单位: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing 100049, China

会议类型: 国内会议

会议名称: 2011年度中国热带作物学会遗传育种专业委员会年会暨学术研讨会

会议地点: 南昌

会议语种:英文

页码: 201-206

在线出版日期: 2011-08-01（万方平台首次上网日期，不代表论文的发表时间）