Study on sequence variants within and near MC4R to identify gene-environmental interaction on childhood obesity in China

摘要：

IntroductionThe melanocortin-4 receptor (MC4R) is expressed primarily in the central nervous system, and is a part of melanocortinergic pathway that regulates food intake and controls energy homeostasis”1”. The MC4R homozygous knock-out mice had maturity-onset obesity, hyperphagia, increased linear growth, hyperinsulinemia, and hyperglycemia ”2” The heterozygous mice had intermediate bodyweights compared with the wild-type and homozygous mice, suggesting the gene dosage effect. In addition, MC4R-knockout mice had reduced metabolic rate.

作者: Hai-Jun Wang Jie-Yun Song Du Wang Jun Ma Yan Wang

作者单位: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China Division of Maternal and Child Health, School of Public Health, Peking University, Beijing, China

会议类型: 国内会议

会议名称: 中华预防医学会儿少卫生分会第九届学术交流会暨中国教育学会体育与卫生分会第一届学校卫生学术交流会暨中国健康促进与教育协会学校分会第三届学术交流会

会议地点: 北京

会议语种:英文

页码: 586-597

在线出版日期: 2011-12-01（万方平台首次上网日期，不代表论文的发表时间）