Imaging tissue acidification with pH-sensitive endogenous amide proton transfer(APT)MRI

摘要：

Introduction It is necessary to characterize metabolic impairments by monitoring alteration in energy substrates，neuronal biomarkers and tissue pH in order to understand ischemic injury 1,2．Amide proton transfer(APT)MRI，a variation of chemical exchange saturation transfer(CEST)imaging，has been increasingly applied for studying ischemic stroke3-6．Here,we evaluated acute stroke with 1H MRS and multi-parametric MRI，and tested whether endogenous APT MRJ may provide quantitative tissue pH mapping and serve as a surrogate metabolic imaging marker for acidosis．Methods Animal model：Permanent middle cerebral artery occlusion(MCAO)was induced in adult male Wistar rats(n=12)，approved by institutional guidelines．Animal plasma glucose level was sampled immediately before MCAO．

作者: Enfeng Wang Jerry S Cheung Phillip Zhe Sun

作者单位: Martinos Center for Biomedical Imaging,Department of Radiology,MGH and Harvard Medical School,Charlestown,MA 02129

会议类型: 国内会议

会议名称: 第二十届中国国际医用仪器设备展览会暨技术交流会、中放磁共振年会暨国际磁共振研讨会

会议地点: 北京

会议语种:英文

页码: 63-64

在线出版日期: 2011-08-18（万方平台首次上网日期，不代表论文的发表时间）