Interferon Regulatory Factor-1 Exerts Inhibitory Effect on Neointimal Formation after Vascular Injury

摘要：

Objective To investigate the effect of interferon regulatory factors (IRFs) on neointimal formation after vascular injury in the mouse, and its possible mechanism.Methods Vascular injury was induced by polyethylene cuff placement around the left femoral artery of IRF-1-deficient mice and C57BL/6J mice. The mRNA expressions of IRF-1, IRF-2, angiotensin II type 2 (AT2) receptor, interleukin-13 converting enzyme (ICE), inducible nitric oxide (iNOS) were detected by RT-PCR and immunohistochemical staining.

关键词： angiotensin apoptosis arteries inflammation remodeling

作者: 李震 汪忠镐 霍小森 王雷永 季锋

作者单位: Vascular Surgery, Aviation General Hospital, Beijing 100012, China Vascular Surgery, Aviation General Hospital, Beijing 100012, China Vascular Institute, Xuanwu ospita Vascular Surgery, Aviation General ospital, Beijing 100012, China

会议类型: 国内会议

会议名称: 第六届国际布加综合征学术大会暨汪忠镐血管论坛、首届中国布加综合征与静脉疾病介入治疗大会

会议地点: 郑州

会议语种:英文

页码: 818-824

在线出版日期: 2010-09-03（万方平台首次上网日期，不代表论文的发表时间）