Bioimpatibility study of magnetosomes formed by Acidithiobacillus ferrooxidans
Magnetotactic bacteria (MTB) are motile prokaryotes that have the ability to propel along geomagnetic field lines. Hallmarks of MTB are intracellular magnetosomes, which are magnetic crystals of either iron oxide, magnetite (Fe3O4), or iron sulfide, greigite (Fe3S4) or iron pyrite (FeS2) enveloped by a phospholipid bilayer membrane. It has been reported that Acidithiobacillus ferrooxidans ”At. Ferrooxidans) is able to produce magnetosomes. Incomparison with fastidious magnetotactic bacteria, At. Ferrooxidans can grow without the drastic regimes of oxidative stress, and the mass cultivation of this bacteria has been easilyavailable. Although there is extensive literature on the biocompatibility of chemosynthetic magnetite nanocrystal, much less information on the biocompatibility of biosynthetic magnetite nanocrystal is available. In the present work, the orthogonal design of experiment was used to optimize the condition of At. Ferrooxidans growth and magnetosomes synthesizing. The results indicated that the optimized conditions of At. Ferrooxidans growth and magnetosomes synthesizing were not identical.
Magnetotactic bacteria Acidithiobacillus ferrooxidans Magenetosomes Biocompatibility Hemolysis assay Micronucleus Test
Lei Yan Shuang Zhang Peng Chen Xiaoxuan Yue Yang Li Zhiliang Xu Hongyu Li
MOE Key Laboratory of Arid and Grassland Ecology, School of Life Sciences, Lanzhou University, Lanzh College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, P GIBT, Gansu Institute of Business and Technology, South of the City Beach 268, Lanzhou, 730010, PR C MOE Key Laboratory of Arid and Grassland Ecology, School of Life Sciences, Lanzhou University, Lanzh
国内会议
兰州
英文
99-100
2011-09-01（万方平台首次上网日期，不代表论文的发表时间）