Strong association of CHRNA3 gene rs 1051730 polymorphism with lung cancer risk: a meta-analysis

摘要：

Association between CHRNA3 gene rs1051730 polymorphism and lung cancer has been widely evaluated, however the results are often irreproducible. We thus aimed to evaluate this association via a comprehensive meta-analysis. Data were extracted from 11 study populations involving 9359 lung cancer patients and 11455 controls, and were analyzed using STATA (vl 1.0). Random-effects model was applied, while addressing heterogeneity and publication bias. Genotype distributions of rs 1051730 polymorphism met Hardy-Weinberg equilibrium in controls for all studies. Allelic comparison indicated that rsl051730 A allele conferred 30％

关键词： lung cancer CHRNA3 polymorphism association meta-analysis

作者: Gu Mingliang Zhang Xuezhi Dong Xiaoqun Qi Yue Wang Xumin Yu Jun Niu Wenquan

作者单位: Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Clinical Laboratory of Biochemistry, Central Hospital of Shengli Oil Field, China Petrochemical Corp Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Cente Department of Epidemiology, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing I State Key Laboratory of Medical Genomics at Ruijin Hospital, Shanghai Jiao Tong University School of

会议类型: 国内会议

会议名称: 2011中国遗传学会大会

会议地点: 乌鲁木齐

会议语种:英文

页码: 117-118

在线出版日期: 2011-07-01（万方平台首次上网日期，不代表论文的发表时间）