Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in Chinese
The T-box transcription factor T-bet is a key regulator for the lineage commitment in CD4 Th1 cells and CD8 T cells by activating the hallmark production of interferon-γ, and its expression level is linked to autoimmune diseases. T-1993C and T-1514C polymorphisms in the TBX21 gene (encoding T-bet) promoter can affect transcription activity.We investigated the distributions of these functional polymorphisms in 84 adult patients with type 1 autoimmune hepatitis (AIH-1) and 318 healthy controls. The influence of the T-1993C polymorphism on transcription and its functional effect by luciferase reporter and EMSAs, and flow cytometric analysis of intracellular T-bet, IFN-? And IL-4 expression in activated CD4+ T cells. Intracellular T-bet staining of polarized CD4 Thl cells from healthy controls corresponding to T-1993C genotypes were analyzed by flow cytometry.
Autoimmune hepatitis TBX21 T-bet single nucleotide polymorphism
Song Chen Qing Mao Yuming Wang Guohong Deng Jirong Li Wenting Tan Wenli Zhao Xiao Luo Yunjie Dan Zhonglan You Xuemei Kuang Jungang Li
Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqi Department of Pediatrics, Chengdu Military General Hospital, Chengdu, China, 610083
国内会议
乌鲁木齐
英文
120-121
2011-07-01（万方平台首次上网日期，不代表论文的发表时间）