原癌基因p53对miR-17-92簇的负向调节在缺氧诱导的细胞凋亡中具有重要作用
Hypoxia remains a major characteristic of tumors. Malignant cell growth requires the presence of a local vascular network that supplies oxygen and nutrients. However，a highly proliferating mass of tumor cells develops faster than the vasculature and rapidly meet up with anavascular environment deficient in oxygen. Hypoxia affects a variety of cell properties such as cellgrowth，apopfosis，metastasis and sensitivity to treatment. Nevertheless，the responses of cells tohypoxia are essential questions in understanding tumor progression，which may lead to novelstrategies for diagnosis and treatment. microRNAs (miRNAs) are about 22 nucleotide RNAmolecules that participate in a wide variety of physiological and pathological cellular processes such as cell differentiation，proliferation，death，metabolism and more recently tumori genesis Recent studies have established a link between a distinct miRNAs expression profile with hypoxiaand global miRNAs expression changes have been described and in some cases shown to correlatewith the clinicopathological features of the tumor. However，there is still few mechanism has been proposed to date and relatively little is known about miRNAs regulation in hypoxia.
poptosis hypoxia miR-17-92 cluster transcriptional repression
颜宏利 薛赓 梅倩 王玉招 刘默芳 陆明华 汤莹 余宏宇 孙树汉
第二军医大学遗传研究所,上海 200433 中国科学院生物化学与细胞生物学研究所,上海 200031 第二军医大学生物物理学教研室,上海 200433 上海长征医院病理科,上海 2000003
国内会议
乌鲁木齐
中文
227-228
2011-07-01（万方平台首次上网日期，不代表论文的发表时间）