Analysis of rescue experiment in Pax 1 knock-down zebrafish reveals the lineage-specific function of the Paxl C-terminus
Gene multi-functionization, by either duplication or co-option of new functions of an original gene, plays important roles in the evolution of animal complexities. Thus comparative analysis of orthologous genes in animals of sharply different complexities, like cephalochordates and vertebrates, can help us to understand the evolution of those complexities. Vertebrate Paxl and its paralog Pax9 derived from a common ancestral gene Pax 1/9 by gene duplication occurred after the divergence between cephalochordates and vertebrates. In vertebrates, Paxl is involved in the development of sclerotome and endodermal pharyngeal pouch. However, Pax 1/9 oi cephalochordate amphioxus is expressed only in the endoderm of the developing pharynx, and not in any mesodermal structures.
Pax 1 gene knock-down evolution amphioxus zebrafish C-terminus
LIU Xin WANG Hua LI Guang HUANG Hui-Zhe WANG Yi-Quan
School of Life Sciences, Xiamen University, Xiamen 361005, China
国内会议
乌鲁木齐
英文
325
2011-07-01（万方平台首次上网日期，不代表论文的发表时间）