ANTIMUTAGENICITY OF BIOLOGICALLY ACTIVE SUPPLEMENT FROM PLANTS AND PROBIOTICS
Among medical plants of native flora, relating to halophytes, certain interest present Limonium genus of Plumhagenaceae family, containing 18 species. Chemical research of compounds, extracted from upper parts and roots of 6 investigated species of Limonium, showed as biologically active compounds (-)-epigallocatechin, (-)-epigallocatechin-3-O-gallate, polymeric proanthocyanidins, myricetin and their glycosids, gallic acsides, glucose, ramnose, galactos, 20 ot-amino acides, including all essential. Exstracts from 6 species of Limonium were tested as modifiers of chemical mutagenesis. Such events as chromosome aberrations were scored.In experiments white breedless rats-male have been used. Laboratory animals were exposed to the subacute influence of fipronil and extracts from L. Gmelinii, L. Myrianthum, L. Popovii. Xenobiotic induced significant increasing of the frequency of aberrant bone marrow cells compare with control values. Chromosome-type as well as chromatid-type aberrations were observed. Testified plant extracts did not exhibit chromosome-breaking activity on rats. The all investigated plant extracts in combination with xenobiotic had protective action and decreased the mutagenicity of fipronil.
Savitskaya I.S. Kolumbaeva S. Zh. Shalakhmetova T. M Zhubanova A.A. Kistaubaeva A.S. Voronova N.V.
Al-Farabi Kazakh National University,Almaty,Kazakhstan
国内会议
乌鲁木齐
英文
346
2011-07-01（万方平台首次上网日期，不代表论文的发表时间）