Defibrillation and resuscitation in a piglet model of pediatric ventricular fibrillation following AHA 2005 guidelines
It is evaluated in this article that whether the AHA protocol was applicable to pediatric ventricular fibrillationpatients. Thirty domestic piglets weighing 7-25 Kg which represented pediatric patients between the ages of l and S yrs wereinduced ventricular fibrillation (VF) with an AC current and randomly divided into AED and manual defibrillator groups. After 2minutes of untreated VF, an adult biphasic AED was used in conjunction with pediatric attenuating electrodes which could deliver50-J shock, and two minutes of cardiopulmonary resuscitation (CPR) inunediately followed it, if VF was not reversed, 70-J shockcombined with CPR was used, and the protocol was repeated five times. The same resuscitation program was exercised on piglets ofmanual defibrillator group. Neurologic alertness score, hemodynamic and myocardial functions were evaluated, autopsy wasroutinely performed to document possible injuries. 50-J shock followed by two minutes of CPR successfully resuscitated 86.7% piglets. Left ventricular ejection fraction and fractional area change were reduced significantly during 3”-4 hrs post-resuscitation andreturned to baseline ranges at the end of 72 hrs. There was no evidence of myocardial and pulmonary damage during autopsy, andneurologic recovery was normal.50 1 biphasic dose delivered through a pediatric padlcable system with AED or a variable dosemanual defibrillator combined with effective CPR successfully terminated VF without adverse effects on myocardial function andsurvival in a piglet defibrillation model for young children 1 to 8 yrs of age, all the experiments show it is in accordance with 2005guidelines.
ventricular fibrillation defibrillator AED CPR
Zhengyu Zhou Yubin Wang Huiying Zhou Meng Huang Huiting Liu Chengtai Hsieh Zhimou Xue
Center for Laboratory Animal, Soochow University, Suzhou, Chinap
国内会议
2011东莞第二届国际小型猪学术论坛暨大型实验动物生物医药研究应用研讨会
东莞
英文
464-469
2011-11-01（万方平台首次上网日期，不代表论文的发表时间）