A class of novel α-heterocyclic carboxaldehyde thiosemicarbazones inhibitors against topoisomerase Ⅱα catalytic activity and iron deprivation as iron chelators

摘要：

　　Thiosemicarbazones are a class of iron chelators that have shown potent anti-cancer activities, some of which are under preclinical or clinical studies.We synthesized a class of novel thiosemicarbazone derivatives which bearing condensed heterocyclic carboxaldehyde moieties.Several compounds exhibited potent cytotoxic activity.Of all the compounds tested, TSC24 showed the best anti-tumor efficacy with IC50 in nanomolar range.

关键词： 硫脲衍生物 化学合成 细胞毒性 抗肿瘤作用

作者: He Huang Qian Ba Qin Chen Linghua Meng Jian Ding Hualiang Jiang Kaixian Chen Hui Wang Hong Liu

作者单位: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medico, Shanghai Institutes for Key Laboratory of Nutrition and Metabo/ism, Institute for Nutritional Sciences, Shanghai Institutes

会议类型: 国内会议

会议名称: 2011年全国药物化学学术研讨会

会议地点: 广州

会议语种:英文

页码: 292-293

在线出版日期: 2011-11-17（万方平台首次上网日期，不代表论文的发表时间）