Tobacco Smoking and Oral Cancer risk:a Meta-analysis
Objective Several epidemiological studies suggest that tobacco smoking increases the risk of oral cancer.No systematic review, however, has been reported to examine how consistent the evidence is across the studies.We undertook a mesa-analysis of epidemiological studies investigating the magnitude relationship between tobacco smoking and oral cancer in order to offer scientific basis for health education and decision of prevention.Methods All case-control studies about tobacco smoking and risk of oral cancer were obtained after retrieving literatures comprehensively.All statistic analyses and heterogeneity test were performed using Rev Man 4.2.8 software.The meta-analysis was applied for calculation of pooled OR value (with 95%CI) of oral cancer.Results There were 14 literatures being accorded with the inclusion criteria.A total of 4508 oral cancer cases and 11725controls were included.There was heterogeneity in the pooled OR estimate across the studies.The combined odds ratio for tobacco smoking related to oral cancer was 2.86(95%CI: 2.16, 3.78).Also, the highest combined odds ratio was belong to America continents (OR=6.45; 95%CI: 5.26, 7.91)and the lowest was in Africa (OR= 1.37; 95%CI:1.05, 1.77).With increasing the amount of smoking, the risk of oral cancer was increasing(the pooled OR value.increased from 2.42 to 4.88).Conclusion Our results clearly indicate that tobacco smokers are at increased risk of oral cancer.The cancer risk can be reduced by controlling of tobacco smoking in different countries.
tobacco smoking oral cancer Meta-analysis
LI Zhonglin WANG Peng XIE Weihong DAI Lping WANG Kaijnan ZHANG Jianying
郑州大学工会 郑州大学公共卫生学院流行病学教研室 郑州大学第一附属医院口腔颌面外科 郑州大学工会 郑州大学公共卫生学院流行病学教研室 郑州大学第一附属医院口腔颌面外
国内会议
西安
英文
244-249
2011-04-19（万方平台首次上网日期，不代表论文的发表时间）