Interaction of MAGED1 with nuclear receptors affects circadian clock function
The circadian clock has a central role in physiological adaption and anticipation of day／night changes．In a genetic screen for novel regulators of circadian rhythms．We found that mice lacking MAGEDl(Melanoma Antigen Family D1) exhibit a shortened period and altered rest-activity bouts．These circadian phenotypes are proposed to be caused by a direct effect on the core molecular clock network that reduces the robustness of the circadian clock．We provide in vitro and in vivo evidence indicating that MAGED1 binds to RORa to bring about positive and negative effectS on core clock genes of Bmal1，Rev-erba and E4bp4 expression through the Rev-Erba／ROR responsive elements(RORE)．Maged1 Is a non-rhythmic gene that，by binding RORa in non-circadian way,enhances rhythmic input and buffers the circadian system from irrelevant．Perturbing stimuli or noise．We have thus identified and defined a novel circadian regulator,Magedl， which Is indispensable for the robustness of the tireadian clock to better serve the organism．
anticipation circadian rhythms locomotor activity MAGED1 RoRa
Xiaohan Wang Ying Xu Jing Tang Lijuan Xing Guangsen Shi Haibin Ruan Xiwen Gu Zhiwei Liu Xi Wu Xiang Gao
MOE Key Laboratory of Model Animal for Disease Study,Model Animal Research Center,Medical School of Nanjing University,Pukou District,Nanjing,China
国内会议
南宁
英文
6-14
2011-09-15（万方平台首次上网日期，不代表论文的发表时间）