Association of CYP3A5*3 with Acute Lymphoblastic Leukemia Susceptiveness in Chinese Han Children
To investigate the association of CYP3A5*3 with acute lymphoblastic leukemia susceptiveness in Chinese han children. Methods: CYP3A5 genotype was analyzed from 172 Chinese han children, including 52 acute lymphoblastic leukemia patients and 120 healthy. PCR-RFLP was used to identify the polymorphism. Results: The allelic frequency of CYP3A5*3 was 0.721 (95％ CI: 0.549, 0.893) in patients while 0.758 (95％ CI: 0.674, 0.842) in healthy controls. No significant difference existed in CYP3A5*3 frequencies between patients and controls (P=0.275), males and females (P=0.432) in the total population. Conclusion: The CYP3A5*3 variant represents a common polymorphism in Chinesehealthy children and ALL, and this polymorphism is poor association with childhood acute lymphoblastic leukemia susceptiveness.
CYP3A5 Polymorphism Acute Lymphoblastic Leukemia
Yan Liu Xiao-tong Lu Qi Sheng Huai-ping Tian A-jing Xu Yue-nian Tang Shu-hong Bu Li-xia Li Jian Zhang
Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Department of Pediatric Hematological, Xinhua Hospital Affiliated to Shanghai Jiaotong University Sc
国内会议
烟台
英文
1-10
1900-01-01（万方平台首次上网日期，不代表论文的发表时间）