Urinary 6β-Hydroxycortisol/cortisol ratio as a signal of CYP3A4 activity in chinese children acute lymphoblastic leukemia patients
The present study establish a simple method for determining the concentration of 6β-hydroxycortisol and cortisol in urinary at same time, to determined the urinary 6β-hydroxycortisol/cortisol ratio, a marker for CYP3A activity in 13 Chinese children acute lymphoblastic leukemia patients compare with 114 health children. First-morning urine specimen was collected from each subject for the quantification of urinary concentrations of cortisol and 6β-hydroxycortisol. In this study, the association of the 6β-OHC/cortisol ratio was higher in children acute lymphoblastic leukemia patients than in health children, while the 6β-hydroxycortisol/cortisol ratio is no significant different between subgroups in health children (P). These findings suggest that high CYP3A4 activity may be a risk factor for children acute lymphoblastic leukemia risk. 6β-hydroxycortisol/cortisol ratio could be consided as a probe childhood acute lymphoblastic leukemia.
childhood acute lymphoblastic leukemia CYP3A4 6β-hydroxycortisol cortisol
A-Jing Xu Jian Zhang Yang Shu Yue-nian Tang Yan Liu Fang Wang Lun Chen Xiao-Tong Lu Huai-Ping Tian Shu-Hong Bu
Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine,Shanghai, C Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicin
国内会议
烟台
英文
1-13
1900-01-01（万方平台首次上网日期，不代表论文的发表时间）