Effects of novel pH-sensitive liposomes with cleavable esterase-catalyzed and pH-response double smart mPEG-Hz-CHEMS on ABC phenomenon
The ABC phenomenon is described as a syndrome of accelerated blood clearance which the repeated injection of polyethyleneglycol-modified (PEGylated) liposomes could cause a rapid clearance of them from the bloodstream, while an increased accumulations in the liver and spleen. In this research, to solve this immune response phenomenon, a novel modified pH-sensitive liposomes with the cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS ) was evaluated. The results indicated that the ABC phenomenon in mice was brought about by repeated injection of conventional PEG-PE-liposomes and was accompanied by a greatly uptake in the liver. However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS-liposomes and was accompanied by a slightly increased uptake in the liver. While repeated injection of mPEG-Hz-CHEMS-liposomes did not induce the ABC phenomenon and there was not an increase in liver accumulation. This finding indicates that the cleavable mPEG-Hz-CHEMS derivative could lessen or eliminate the ABC phenomenon induced by repeated injection of PEGylated liposomes. These studies have shed some light on a solution to the ABC phenomenon of cleavable PEG-Hz-Cholesterol derivative in nanoparticles.
Accelerated blood clearance (ABC) Double smart Cleavable mPEG-lipid derivatives pH-sensitive liposomes
Daquan Chen Yan Shen Wanhui Liu Hongjie Mu Jiahong Tang Leiming Zhang Kaoxiang Sun
School of Pharmacy, Yantai University, Yantai 264005, China College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
国内会议
烟台
英文
1-18
1900-01-01（万方平台首次上网日期，不代表论文的发表时间）