In vivo characteristics studies on the drug nanonanosuspensions
Over the last decades, the formulation of drugs as nanocrystals has successfully evolved into a mature drug delivery strategy for the formulation of the poorly soluble drugs because of their simplicity in preparation and general applicability. During the last decade of the 20 century lots of works have been done to study the technologies leading to the nanocrystals and their in vitro physical and chemical properties, such as their stabilities, enhanced saturation solubility and dissolution rate. In the last ten years, many researchers focused on the in vivo characteristics of the nanocrystals in animals. In this article, in vivo characteristics of the nanocrystals (obtained by different techniques) exhibited in animals after administered through different route were reviewed, and the advantages of the nanocrystals in the aspect of the safety, pharmacodynamics and pharmacokinetics shown in different administration were discussed.
Poorly soluble drugs Nanosuspensions Bioavailability Precipitation Wet milling High-pressure homogenization Pharmacokinetics
Lei Gao Guiyang Liu Jianli Ma Xiaoqing Wang Liang Zhou
Department of Pharmacy, The First Affiliated Hospital of General Hospital of PLA, 51 Fucheng Road, Beijing 100048, China
国内会议
烟台
英文
1-12
1900-01-01（万方平台首次上网日期，不代表论文的发表时间）