Associations of type 2 diabetes gene polymorphisms
Objective: Metabolic syndrome ( MS ) is characterized by abdominal obesity, hypertension,dyslipidemia, and glucose intolerance. It is a combination of these disorders that increase the risk of cardiovasculardisease and type 2 diabetes mellitus ( T2DM ) . Recently, novel risk loci for T2DM, single nucleotidepolymorphism( SNP ) rs290487 in transcription factor 7-like 2 ( TCF712 ) , rs9465871 in cyclin-dependent kinase 5( CDK5 ) regulatory subunit associated protein 1-like 1 ( CDKAL1 ) , rs1359790 in chromosome 13q31.1 wereidentified in Chinese populations. However, evidence of functions of the three above mentioned SNPs is relativelyscarce, especially in Chinese populations. In addition, application of the above T2DM susceptibility SNPs forthe prevention of metabolic syndrome in healthy populations has not yet been examined.<br> Conclusion: We conclude that markers located within the genes TCF712-rs290487, CDKALl rs9465871 and 13q31.1-rs1359790 are neither associated with metabolic syndrome nor metabolic profiles related to this syndrome in a samplefrom Shanghai. And, the risk allele of rs9465871 is significantly associated with elevated HbA1c levels in non-diabeticfemales. The present study may shed some new light on biological pathways of the above gene polymorphisms by whichconferring risk to T2DM in Chinese population. More and larger sample size studies are needed to confirm our results.
代谢综合征 2型糖尿病 发病机制 转录因子
JIANG Jun-yi RUAN Xiao-nan QIU Hua MO Miao XU Wang-hong
Department of Epidemiology,School of Public Health,Fudan University；Key Laboratory of Public Health Department for Chronic Disease Prevention and Control,Pudong New Area,Shanghai Center for Disease Co
国内会议
北京
英文
60-61
2011-11-23（万方平台首次上网日期，不代表论文的发表时间）