Caenorhabditis elegans ucp-4 regulates fat metabol
Uncoupling proteins, a family of proton carriers located in the inner mitochondrial membrane, have important functions in energy metabolism and free radical generation that are relevant to mitochondrial function. Five family members have been identified, UCP1-5,that have distinct tissue distributions, and differences and similarities in physiological function. Uncoupling protein 4 (UCP4) is highly expressed and has a unique function in brain. UCP4 appears to be involved with metabolism in neurons and adipocytes, but conclusions on this protein have been controversial. Here, we used Caenorhabditis elegans to explore the functions of ucp-4, particularly in fat metabolism. Our results showed that UCP4 knockdown induced an obese phenotype and impaired the insulin-like pathway, possibly via oxidative stress in C. elegans. This highlights the importance of studying the role of ucp-4 in fat metabolism.
解偶联蛋白4 脂肪代谢 秀丽隐杆线虫
Chenbo Ji Xirong Guo
Department of Pediatrics,Nanjing Maternal and Child Health Hospital of Nanjing Medical University,Nanjing 210004,China Institute of Pediatrics,Nanjing Medical University,Nanjing 210029,China
国内会议
上海
英文
64-70
2011-10-26（万方平台首次上网日期，不代表论文的发表时间）