Immortalized mesenchymal stem cells:an alternative
Objective： Mesenchymal stem cells (MSCs) can be induced to differentiate into neuronal cells underappropriate cellular conditions and transplanted in brain injury and neurodegenerative diseases animalmodels for neurorestoratology studies. In contrast to the embryonic stem cells (ESCs), MSCs are easilysubject to aging and senescence because of their finite ability of self-renewal. MSCs senescence seriouslyaffected theirs application prospectsas a promising tool for cell-based regenerativemedicine and tissueengineering. In the present study, we establish a reversibleimmortalized mesenchymal stem cells (IMSCs)line by using SSR#69 retrovirus expressing simian virus 40 large T (SV40T) antigen to solve these problemsof MSCs.
间充质干细胞 神经元分化 神经修复
Min Gong Yang Bi Wei Jiang Yun Zhang Nali Hou Jie Chen Tingyu Li
Children”s Nutrition Research Center,Childrens Hospital of Chongqing Medical University,Chongqing 400014,China Ministry of Education Key Laboratory of Child Development and Disorders；Key Laboratory of Pediatrics in Chongqing；Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,Chongqing 400014,China
国内会议
上海
英文
198
2011-10-26（万方平台首次上网日期，不代表论文的发表时间）