Evaluation of global DNA hypomethylation in human
Objective To identify the differences of 5-methylcytosine (5-MC) level between primary prostatecancer tissues (PCTs), prostate cancer-adjacent benign tissues (PCABTs), low-grade prostaticintraepithelial neoplasia (LGPIN), and high-grade prostatic intraepithelial neoplasia (HGPIN), andfurther analysis the 5-MC alterations in prostate cancer with pathologic grade and clinicalprognosis.Materials and methods Immunohistochemistry method with a 5-MC monoclonal antibody wasused to identify the 5-methylcytosine (5-MC) levels in PCTs, PCABTs, LGPIN, and HGPINspecimens in the present study. Statistical analysis with SPSS software (SPSS Inc.,Chicago, IL)was used to compare differences of 5-MC levels in the four groups and evaluate the 5-MCalterations in prostate cancer with pathologic grade and clinical prognosis.
免疫组织化学 前列腺癌 前列腺上皮内肿瘤 病理分级 临床预后
Bo Yang Hang Sun Jianlin Yuan Feng Zhang
Department of Urology Xijing Hospital,Fourth Military Hedical University State Key Laboratory of Cancer Biologyt Department of Pathology,Xijing Hospital, Fourth Military Med
国内会议
福州
英文
258-259
2011-09-16（万方平台首次上网日期，不代表论文的发表时间）