Dexamethasone increased PTEN expression in A549 celts
”Phosphatase and tensin homolog deleted on chromosome 10” (PTEN) is mostly considered to be a cancer-related gene, and has been suggested to be a new pathway of pathogenesis of asthma. The purpose of this study was to investigate the effects of the glucocorticoid, dexamethasone, on PTEN regulation. The human A549 cell line was used to explore the possible mechanism of action of dexamethasone on human PTEN regulation in vitro. A luciferase reporter construct under the control of PTEN promoter was used to confirm transcriptional regulation in response to dexamethasone.
哮喘 地塞米松 调节机制 PTEN基因
ZhenHua Ni JiHong Tang ZhuYing Cai Wei Yang Lei Zhang Qingge Chen Long Zhang XiongBiao Wang
Department of Respiratory Medicine, Putuo Hospital, Shanghai
国内会议
2011中华医学会呼吸病学年会暨第十二次全国呼吸病学学术会议
广州
英文
830-831
2011-09-15（万方平台首次上网日期，不代表论文的发表时间）