Why there is Difference in Urine Albumin Values among Assay Systems
Human serum albumin(HSA)is a non-glycoprotein with a molecular weight of 66000 synthesized mainly in the liver.Albumin present in urine iS of serum origin.Its value is thought to be mainly reflected by size and charge selectivity of glomerular basement membrane.In our recent data reference intervals in 148 healthy individuals were 4.56 me,/gCr in median ranging from 0.4 1 to 27.74 mg/g/Cr.Microalbuminuria is defined in the value of spot urine.30 to 299 mg/gCr,which should be detected at least in two out of three examinations.It is a well—established diagnostic and prognostic indicator for diabetic nephropathy.Now much more attention is being focused on the value below microalbuminuria threshold.10W—grade albuminuria，for a predictive and risk factor for morbidity and mortality of cardiovascular events.More than 20 immunoassays with different principles have been commercially available in Japan.According to a Survey by the Joint Committee three different concentrations of pooled urines were sent to 86 clinical laboratories all over Japan.The difference was noted in the value between clinical laboratories that reflected the status of poor standardization.
Yoshihisa Itoh
Department of Laboratory Medicine,Asahikawa Medical University,Japan
国内会议
中华医学第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议
北京
英文
11-12
2011-05-24（万方平台首次上网日期，不代表论文的发表时间）