High levels of FCgama R3A and PRF1 expression in NK and NKT ceils from patients with primary biliary cirrhosis
Primary biliary cirrhosis(PBC)is a progressive autoimmune liver disease characterized by the chronic inflammation and destruction of intra-hepatic small bile ducts，leading to liverfmrosis，cirrhosis，and eventual liver failure,The cellular components in human innate immune system，such as natural kill cells fNK)，natural kill T cells 0”roT)，monocytes，macrophages，and dendritic cells(DC)，represent a first—line defensive system against microorganisms，and their activities rely on receptors that recognize molecules in pathogens or envkonmental factors.Natural killer (NK)cells and NKT cells are critical effectors of the innate immune system.However，little is known about the frequency and function ofNK cells and NKT cells in patients with PBC.In the current study，we compared the levels of FCyR3A，TYROBP，and PRFl expression in NK and NKT cells，and examined the potential relationship of their expression with liver function and disease severity in a Chinese population of PBC and healthy subjects.
Xi Li Fengchun Zhang Yongzhe Li Danxu Ma Lei Zhang Ting Zhang Li Wang Qun Shi Qian Wang Qingjun Wu Xuan Zhang
Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Unio Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Unio
国内会议
中华医学第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议
北京
英文
236-237
2011-05-24（万方平台首次上网日期，不代表论文的发表时间）