The Relationship between HPV E7 and HLA Class Ⅰ Expression and the Molecular Evidences in HPV-16 E7-transfected Cells
Cervical cancer is one of the most common CanCelS worldwide.Epidemiologic and molecular evidence has demonstrated that high-risk human papillomaviruses(HPVs)are the main etiologic agenm in the progression of cervical cancer，with at least 90％of cervical carcinomas harboring HPV DNA.E6 and E7 genes encode the major HPV oncoproteins.The E7 protein of high一risk HPV types disturbs cell cycle control and down—regulates components of the antigen presentation pathway，suggesting a role for E7 in tumor immune evasion.This study was aimed to determine whether HPV.1 6 E7 DNA load and expression ofHLA class l was correlated in cervical lesions(cervicitis， CIN， cervical squamous carcinomas and adenocarcinoma samples)，We also study these molecular evidences in HPV-16E7-transfected cells
Wei Li Xin Zhang Chuanxin Wang Jinfeng Wang Lutao Du Lili Wang Shun Wang
Department of Clinical Laboratory,Qilu Hospital, Shandong University,Jinan,Shandong,China
国内会议
中华医学第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议
北京
英文
271-272
2011-05-24（万方平台首次上网日期，不代表论文的发表时间）