Updated Meta-Analysis on Genetic Predisposition of Four Variants at NRAMP1 (SLC11A1)Gene to Tuberculosis
A previous meta-analysis was performed to assess the association between variations in NRAMP l and tuberculosis(TB)risk but its limitations were that it did not report genotype comparative results，and not discuss the association with extra-pulmonary TB(EPTB).So，we carded out an updated meta-analysis to further investigate the association between NRAMP1 and TB susceptibility.searched databases(PUBMED， EMBASE and ISI Web of Knowledge)up to July 2010 using”tuberculosis”‘‘NRAMPl，”SLCllA1”“solute carrier family 11 member l”‘”natural resistance-associated macrophage protein 1”，also performed a manual search from relevant original studies.We extracted information on first author,publication year country of origin，age of population，control sources and genotype distribution.Summary ORs and corresponding 95％CIs were estimated by fixed effects or random effects model according to it value.To check for publication bias，a funnel plot，using Egger”s linear regression method，Was constructed.
Dong-dong Li Xin Hu Meng-na Zuo Chuan-min Tao Bing-WU Ying Lan-lan Wang
Department of lab med,West China Hospital of S.C.U.
国内会议
中华医学第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议
北京
英文
325-326
2011-05-24（万方平台首次上网日期，不代表论文的发表时间）