Promising diagnostic model of pulmonary tuberculosis constructed by using MALDI-TOF MS technology and weak cationic exchange magnetic beads
Pulmonary tuberculosis(TB)is an infectious disease that disturbs the balanced status of public health.Accurate diagnosis of TB would effectively help controlling the disturbance.Since proteomic fingerprint profiling by matrix-assisted laser desorption-ionization time of flight mass spectrometry(MALDI-TOF MS)combined with pretreatment ofmagnetic beads is a robust approach for the investigation of new biomarkers and lots of related researches have built up useful classification trees by using this technique，we used this technology to establish a diagnostic model for TB inthis study.178 serum samples involving 75 patients with TB(43 were smear-positive patients of TB(SPP-TB)，32 were smear·negative patients of TB(SNP-TB))，other 43 individuals serving as disease control group(DC group)including 16 lung cancer，20 pneumonia，4 chronic obstructive pulmonary disease，3 bronchiectasia and 60 healthy controls (HC group) were involed in this study.
Chuiwen Deng Minggui Lin Chaojun Hu Yanfeng Li Yang Gao Xiaoxing Cheng Fengchun Zhang Mei Dong Yongzhe Li
Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Unio ivision of Research,Institute of Tubereulosis,309th Hospital of Chinese PLA,Beijing Department of Immunology,Institute of Basic Medical Sciences,Peking Union Medical College,Chinese A Department of Clinical Laboratory,309th Hospital of Chinese PLA,Beijing
国内会议
中华医学第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议
北京
英文
332
2011-05-24（万方平台首次上网日期，不代表论文的发表时间）