Enantioselectivity of an Organophosphate Insecticide:Toxic and Mechanistic Aspects
Enantioselectivity occurs widely in the environmental behaviors and toxicity of chiral contaminations such as pesticides. However，the investigation on the enantioselective toxicology mechanisms remains very limited especially in food safety. In this study，we used fenamiphos and malathion as the models of organophosphate insecticide to study the enantioselectivity in aquatic toxicity and the inhibition potential toward acetylcholinesterase（AChE） in rat pheochromocytoma 12（PC 12） cell line. Furthermore，we carried out molecular docking to explain the mechanisms of enantioselective toxicity of these two chemicals. This study made auspices in understanding the impact of stereochemistry on assessment of toxicological effects in food safety. Given the widespread use of chiral pesticides，a more comprehensive understanding of the significances of enantioselectivity is imperative for improving food safety assessment and regulation of these pesticides.
对映选择性 分子对接 食品安全 有机磷杀虫剂 手性农药
Cui Wang Quan Zhang Meirong Zhao Weiping Liu
Research Center of Environmental Science, College of Biological and EnvironmentalEngineering, Zhejiang University of Technology, Hangzhou 310032, People’s Republic of China
国内会议
大连
英文
593
2008-11-05（万方平台首次上网日期，不代表论文的发表时间）