Kinetic Evidence of Plant-esterase Inhibited by Organophosphours Pesticides
Although there are many studies about the inhibition of organophosphours pesticides（OPs） against plant-esterase，most of which emphase on the effect of reaction time，temperature and PH，the toxicity of pesticides against plant-esterase with respect to enantioselectivity has so far received limited attention. In this study，the kinetic constants of plant-esterase inhibited by the racemate and enantiomers of malaoxon，isomalathion，and methamidophos were investigated. The inhibition on plant-esterase tested with optically pure stereoisomers of malaoxon，isomalathion and methamidophos showed its stereoselectivity. As for malaoxon，and isomalathion，R-configure were more toxic than the S-configure enantiomers to test esterase. In contrast，the S-methamidophos was a stronger inhibitor to test esterase. These results suggest that the biotoxicity of chiral OPs to nontargeted organisms is enantioselective and therefore should be reevaluated with their pure enantiomers.
甲胺磷 植物酯酶 对映体选择性 生物毒性
胡晓燕 Chunmian Lin
浙江工业大学生物与环境工程学院 Research Center of Environment Science, Zhejiang University of Technology, Hangzhou310032, China
国内会议
大连
英文
594
2008-11-05（万方平台首次上网日期，不代表论文的发表时间）