Mechanisms of Synapse Formation and Synaptic Plasticity
The human brain contains billions of neurons to receive and integrate a host of elec-trical andbiochemical signals. Efficiency in communication among neurons is made po-ssible by synapses,contacts formed between two neurons. Despite significant progres-s in our understanding of synapseanatomy，relatively little is known about how diff-erent components/molecules are assembled togetherand how the disruption of this pro-cess and synapse function causes psychiatric and neurologicaldisorders. The focus o-f our lab is to understanding the mechanisms underlying synapse formation andwhat g-oes wrong at synapses under pathological conditions. Our studies aim at identificat-ion oftargets and development of potential therapeutic strategies for treating diso-rders whose pathogenesisinvolves abnormal synaptic structure and function. These i-nclude psychiatric disorders such asschizophrenia，autism，and depression and neuro-logical disorders such as muscular dystrophy，spinalcord injury，and epilepsy.
突触可塑性 突触结构 神经元 精神紊乱
Lin Mei
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia
国内会议
长沙
英文
222-225
2008-07-25（万方平台首次上网日期，不代表论文的发表时间）