Migration of Neural Progenitors after Cerebral Ischemia
Ischemia causes seemingly irresolvable damage to brain. The discovery of the neural stem cells andthe subsequent observations of increased neurogenesis in adult brain f-ollowing ischemia has led tooptimism that the post-ischemic brain can be repaired a-t least to a certain extent. It is clear that we arejust starting to understand theintegration of various molecular regulators of neurogenesis. As one ofthe most impo-rtant steps of neurogenesis after stroke，migration depends on cooperative signalingbyhighly localized attractants，repellants and guidance cues. The mechanisms seem si-milar to thoseinvolved in developmental axon outgrowth and neuronal migration. Ther-efore，the expectation is thatmore molecular regulators of neuroblast migration andtheir interactions will be identified bycontinuing the investigation of developmenta-l guidance molecules within this adult system after braininjury.
神经干细胞 脑缺血 分子调节剂 轴突生长 神经元迁移
Wen-lei Li Shan Ping Yu 魏玲
Department of Pathology, Medical University of South Carolina Department of Pathology, Medical University of South Carolina Department of Pharmaceutical Sciences, s首都医科大学临床医学
国内会议
长沙
英文
364-374
2008-07-25（万方平台首次上网日期，不代表论文的发表时间）