Myosin X Acts as a “Vehicle” for Neuronal Netrin Receptors
(0) Neuronal growth cones，tips of neurites，not only probe the surrounding matrix in se-arch of permissivesites to form adhesions，but also sense the guidance cues（e.g，netrin-1) to change the direction ofneurite elongation. The coordination among differ-ent environmental cues and the coupling betweenthe sensory and motor activities at the growth cones are essential for axonal guidance. Our recentstudies suggest a roleof myosin X（Myo X)，an unconventional myosin，as a “vehicle” traveling onthe acti-n filament based “highways” to deliver receptors for growth cone sensory function-s. Thispresentation will specifically discuss how Myo X delivers netrin-1 receptor,DCC（deleted incolorectal cancer)，to the tips of neurites and regulates netrin-1 fu-nctions.
肌球蛋白 神经元 神经末梢神经 轴突生长
Wen-Cheng Xiong
Institute of Molecular Medicine & Genetics, Medical College of Georgia
国内会议
长沙
英文
414-415
2008-07-25（万方平台首次上网日期，不代表论文的发表时间）