The study of NDRG1 ezpression in esophageal squamous cell carcinoma
To study the expression of N - myc downstream regulated gene 1(NDRG1) in e-sophageal squamous cell carcinomas. Method;The S -P immunohistochemical method was employed to detect the expression of NDRG1 in 49 cases of esophageal squamous cell carcinoma, mucosa adjacent to cancer and normal mucosa of esophageal carcinoma. Results: 1) There were no difference in the positive expression rate of NDRG1 protein in cancerous tissues, mucosa adjacent to cancer and normal mucosa ( P > 0. 05) ,but protein expression levels were different. In normal mucosa , mucosa adjacent to cancer and cancerous tissues, the expression rate in low expression level( + ) were: 8.2％ ,65.3％ ,81.6％ ; the expression rates of high expression level( + + ) were: 87.7％ ,13.0％ ,8.1％ , and they had significantly difference ( P <0.01). 2) The protein expression rates of different differentiation levels( High level to low level) of e-sophageal carcinoma were 85.7％ ,91.3％ ,91.7％ , they had no difference (P> 0.05).3) There were no difference of protein expression rates in esophageal carcinoma no matter they had or hadn,t lymphnode metastasis. Conclusions; The protein expression of NDRG1 is lower in esophageal squamous cell carcinoma, and hasn,t related to the differentiation levels of esophageal carcinoma and with or without lymphnode metastasis . The low expression of NDRG1 may be related to the occurring of esophageal carcinoma.
食管鳞状细胞癌 NDRG1表达 免疫组化法 蛋白表达率 淋巴结转移
Fucheng He Yunhang Zhang
Henan Key Laboraty of Tumor Pathology
国内会议
郑州
英文
93-95
2005-09-16（万方平台首次上网日期，不代表论文的发表时间）