Study on Relationship between Metabolism of Cinnamic Acid and Cytochrome P450
Objective：Studied the metabolism of Cinnamic Acid in homogenized liver of rats. To screen the CYP450 enzyme，which participate on metabolism of Cinnamic Acid. And then supply the evidence for rational administration. Methods：The content of Cinnamic Acid in homogenized liver was measured by the reversed phase HPLC. Analysis effects of inductors and inhibitors on metabolism of Cinnamic Acid. Results：The metabolic rate of ?NF group，the specific CYP1A inductor，was higher than control group significantly. But，PB and DEX group，the main CYP2B and CYP3A inductor，respectively，had no significant difference among these and control groups. Further more,a-NF，the CYP1A inhibitor，could inhibit metabolism of Cinnamic Acid significantly. Conclusion：CYP1A is the major enzyme in metabolism of Cinnamic Acid. The medicine，which have induct and inhibit effects on CYP1A，may have interaction with Cinnamic Acid.
肉桂酸 细胞色素P450 合理用药 药物代谢 反相高效液相色谱
Li Wenlan YU Yingying JiYubin Ren Xiaolei XU Dong
Center of Research and Development on Life Sciences and Environmental Sciences，HarbinUniversity of Commerce，Harbin 150076，China;Engineering Research Center of NaturalAnticancer Drugs,Ministry of Education，Harbin University of Commerce，Harbin 150076，China
国内会议
石家庄
英文
1-7
2008-10-18（万方平台首次上网日期，不代表论文的发表时间）