Efficiency and mechanisms of sinomenine HCl used as a potential absorption enhancer
The objective of the present investigation was to understand efficiency and mechanisms of sinomenine hydrochloride used as absorption enhance agent for difference molecular weight model drugs. The different characteristics model drugs(Cimetidine，Vitamine C，Rutin，Luteolin and Insulin)were used in this study as well as sinomenine hydrochloride was employed as absorption enhance agent. Sinomenine hydrochloride was tested in vitro for their ability to decrease the Trans Epithelial Electrical Resistance(TEER)of Caco-2 cell monolayers compare to Ntrimethyl chitosan chloride(TMC)at same concentration. Furthermore，sinomenine hydrochloride was tested as transport enhancer of difference model drugs. In vitro studies showed that sinomenine hydrochloride was able to induce a concentration dependent decrease in the TEER values and a lower cell toxicity of the Caco-2 monolayers. Papp value of all the model drugs show significant increase with sinomenine hydrochloride addition compare to the groups without sinomenine hydrochloride. The mechanisms of sinomenine hydrochloride increase drugs absorption by open the tight junction，inhibition P-gp efflux and anti-degradable，respectively.
青藤盐酸 吸收促进剂 药物吸收机制 模型药物
Zhilei Lu Weiyang Chen Josias H.,Hamman
School of Pharmacy, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa School of Pharmacy, Tshwane University of Technology, Private Bag X680, Pretoria,0001, South Africa
国内会议
石家庄
英文
1-26
2008-10-18（万方平台首次上网日期，不代表论文的发表时间）