From Antifungal Drug Target to New Candidate Drug: Molecular Modeling, Chemical Synthesis and Site-directed Mutagenesis
During the past two decades，the life threatening infections caused by pathogenic fungi have become increasingly common，especially in individuals with immunocompromised hosts，such as patients undergoing anticancer chemotherapy or organ transplants and patients with AIDS. Clinically，candidosis，aspergillosis and cryptococcosis are three major fungal infections in immunocompromised individuals. Moreover，dermatomycoses，such as toenails and tinea pedis，are among the most widespread human superficial and cutaneous fungal infections. However，the current antifungal therapy suffers from drug related toxicity，severe drug resistance，nonoptimal pharmacokinetics and serious drug-drug interactions. Therefore，there is an emergent need to develop novel antifungal drugs with higher efficiency，broaderspectrum and lower toxicity.
抗真菌药物 分子模拟 化学合成 定点突变
SHENG Chun-quan, ZHANG Wan-nian
School of Pharmacy, Military Key Laboratory of Medicinal Chemistry, SecondMilitary Medical Universit School of Pharmacy, Military Key Laboratory of Medicinal Chemistry, Second Military Medical Universi
国内会议
石家庄
英文
1-4
2008-10-18（万方平台首次上网日期，不代表论文的发表时间）