Compare drug release profiles of water poor soluble drugs from a novel chitosan and polycarbophil interpolyelectrolytes complezation (PCC) and hydrozylpropyl - methylcellulose (HPMC) based matriz tablets
(0) The aim of this study was to compare the drug release behaviours of water poor soluble drugs from an interpolyelectrolyte complex(IPEC)of chitosan with polycarbophil(PCC)and hydroxylpropylmethylcellulose(HPMC)based matrix tablets. A novel interpoly-electrolyte complex(IPEC)of chitosan with polycarbophil(PCC)was synthesized and characterized. Water poor soluble drugs Hydrochlorothiazide and Ketoprofen were used in this study as model drugs. Polymers(including PCC，HPMC K100M and HPMC K100LV)based matrix tablets drug controlled release system were prepared using direct compression method. The results illustrate PCC based-matrix tablets offer a swelling controlled release system for water poor soluble drug and drug release mechanism from this matrix drug delivery system can be improved by addition of microcrystalline cellulose(Avicel). Analysis of the in vitro release kinetic parameters of the matrix tablets，PCC based matrix tablets exhibited similar or higher drug release exponent(n)and mean dissolution time(MDT)values compared to the HPMC based matrix tablets. It demonstrated that PCC polymer can be successfully used as a matrix controlled release system for the water poor soluble model drugs such as hydroxylpropylmethylcellulose(HPMC).
药物释放 壳聚糖 HPMC法 羟丙基甲基纤维素
Zhilei Lu Weiyang Chen, Eugene Olivier Josias H.,Hamman
Department of Pharmaceutical Sciences, Tshwane University of Technology, PrivateBag X680, Pretoria, 0001, South Africa
国内会议
石家庄
英文
1-36
2008-10-18（万方平台首次上网日期，不代表论文的发表时间）