New Tazanes from the Leaves of Tazus cuspidata and T. canadensis

摘要：

OBJECTiVE：To study the constituents of Taxus cusipidata and T. canadensis leaves. METHODS: The constituents were extracted with methanol and isolated by column chromatography on silica gel，prep-TLC and prep-HPLC. The structures were determined on the basis of 1D and 2D NMR as well as MS spectral analyses. MTT method was used to evaluate the cytotoxicities of the three diterpenoids. RESULTS: Eight compounds were isolated and identified. CONCLUSION: Compounds 2,3,5-9 have not previously been reported from the titled plants. Compound 7 was a new taxane with a novel skeleton. Compound 8 showed weak growth inhibitory activities against T-98 and MM1-CB.

关键词： 东北红豆杉 新紫杉叶 MTT法 T.canadensis 二萜含量

作者: Manli ZHANG, Junqian LIU Changhong HUO Qingwen SHI, Yucheng GU3

作者单位: School of Pharmaceutical Science, Hebei Medical University, 361 Zhongshan East Road, 050017,Shijiazh The First Hospital of Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, HeBei Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK

会议类型: 国内会议

会议名称: 2008中国药学会学术年会暨第八届中国药师周

会议地点: 石家庄

会议语种:英文

页码: 1-22

在线出版日期: 2008-10-18（万方平台首次上网日期，不代表论文的发表时间）