Genetic Study of Alzheimer”s Disease in Mainland Chinese
Lack of an association between Alzheimer”s disease and the cystatin C (CST3) gene G73A polymorphism in Mainland Chinese. Dement Geriatr Cogn Disord. 2008;25(5):461-4. Alzheimer”s disease (AD) is a complex multifactorial disorder involving a number of genetic and environmental factors. Cystatin C (CST3)，which belongs to the type II cystatin gene family，is a potent inhibitor of lysosomal proteinaseso Immunohistochemical studies have demonstrated the colocalization of the β-amyloid (A-beta) and cystatin C peptides within arteriolar walls in the AD brain. The G73A polymorphism of the CST3 genemay be associated with AD development. To investigate a possible association between the CST3 G73A polymorphism and late-onset AD (LOAD) in Mainland Chinese，we examined 281 LOAD patients and 376 healthy controls. All subjects were genotyped for CST3 and apolipoprotein E (APOE). There were no significant differences in the CST3 genotype or allele frequencies between the cases and the controls. Likewise，with the stratification of the APOE epsilon4 status，no statistical difference was observed between the cases and the controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD in Mainland Chinese.
Genetic Study Alzheimer polymorphism
Wang B Li S Xie YC Peng D Wang J Zhou S Li S Ma X Jin F Wang L Zhang P Yang Z Zhang C Lu Z Shi X Zheng W Wan C Zhang D Zheng C
National Institute of Geriatrics,Beijing Hospital,Ministry of Health,Beijing 100730,China;E-Mail:yangze016@yahoo.com.cn
国内会议
大连
英文
128-135
2008-09-19（万方平台首次上网日期，不代表论文的发表时间）