Tenuigenin inhibits beta-secretase and decreases amyloid-beta protein in vitro

摘要：

Our study was to demonstrated whether Tenuigenin，an extract of Polygala tenuifolia willdenow，can decrease A . And its mechanism.”Method” Tenuigenin was extracted from air-dried roots of Polygala tenuifolia willdenow .The roots (1000g) were ground and refluxed with ethanol (95％ v/v) for three times (3h each)，the extract was combined and evaporated in vacuo，and the yielded residue was suspended in water and extracted successively with petroleum，chloroform and n-butanol. The n-butanol extract was subjected to a macroporous resin D101 column，the adsorbed material was eluted successively with H2O，then 20，70 and 95％ ethanol，the 70％ ethanol eluate was evaporated to dryness (Tenuigenin fraction). Tenuigenin was composed of Tenuigenin A，B，C，D，E，F，G，which were identified by chromatogram.

关键词： Tenuigenin inhibit Polygala tenuifolia chromatogram

作者: Jianbao Lv Hongxiao Jia Yong Jiang Yan Ruan Zhonghua Liu Weihua Yue Konrad Beyreuther Pengfei Tu Dai Zhang

作者单位: Institute of Mental Health,Peking University,Beijing,China Beijing Anding Hospital Affiliated to Capital University,Beijing,China The College of Pharmacy,Peking University,Beijing,China Center for Molecular Biology,University Heidelberg,Im Neuenheimer Feld 282,Heidelberg,Germany. Institute of Mental Health,Peking University,No. 51 Hua Yuan BeiRoad,100083 Beijing,China. E-mail: l

会议类型: 国内会议

会议名称: 2008年全国抗衰老与老年痴呆学术会议

会议地点: 大连

会议语种:英文

页码: 26-29

在线出版日期: 2008-09-19（万方平台首次上网日期，不代表论文的发表时间）