Ezperimental Studies on HA/TCP with Recombinant Human Bone Morphogentic Protein-2 for Ostioporotic Bone Defect Repair
Objective To evaluate the effect of rhBMP-2/HA-TcP composite on repairing bone defect in osteoporotic rats.Methods Thirty female SD rats(8 monks old)were randomly divided into two groups.In experimental groupovariectomy was performed and in control group sham operation was received.Twelve weeks after surgery,cylindricaldefect which diameter is 3.0 mm and depth is the CO-width ofcortical bone and cavitas mcdullaris were performed on bothcondyles offemur.All defects in experimental group were randomly divided into two groups and were implanted:HA/TCPgroup and rbBMP-2/HA-TCP group.The defects in control group Were all implanwA by rhBMP-2/HA-TCP composites.The effect of bone defect healing WaS evaluated in the 4th、8th and 12th weeks after implanting by histomorphology、radiology、bone mineral density(BMD) and vitodynamics.
rhBMP-2 Osteoporosis Defect Rerpair
DUAN Wangpign ZHANG Min LI Gang WEI Xiaochum
Department of ORTHOPAEDICS the 2nd Affiliatde Hosital of Shanxi Medical Univeristy,Taiyuam,030001 The Affiliated Hospital of North Irish Queen Univeristy,British
国内会议
北京
英文
28-31
2007-10-19（万方平台首次上网日期，不代表论文的发表时间）