Ezpression and Pathological Significance of Inducible Nitric Ozide Synthase Ezpression in Osteosarcoma of the Jaws
Objective：The aim of the present study was to examine the expression status of inducible nitric oxide synthase(iNOS) in osteosarcoma of the jaw,and its relationshipswith tumor angiogenesis and clinicopathological characteristics． Conclusion：Osteosarcoma of the jaw was associated with overexpression of iNOS，which correlated with tumor microvessel densitv．iNOS expression furthermore correlated with the size，pathological grade，and clinical’stage of the osteosarcoma,and also with clinicopathological characteristics such as primary occurrence or recurrence of tumors．There was no correlation with metastasis．iNOS may promote tumor angiogenesis in osteosarcoma of the jaw,and so may represent an important target in anti-tumor therapy．
诱导型一氧化氮合酶 骨肉瘤 临床病理 肿瘤血管生成
Chen Wei-liang Feng Hong-jie LiJin-song Li Hai-gang
Department of Oral and Maxillofacial Surgery,the Second Affiliated Hospital,Sun Yat-Sen University,G Department of Oral and Maxillofacial Surgery,Hangzhou First People”s Hospital,Hangzhou，310006,Zhejia Department of Pathology,the Second Affiliated Hospital,Sun Yat-Sen University,Guangzhou，510120,Guang
国内会议
第三次全国口腔颌面—头颈肿瘤综合治疗研讨会暨中华口腔医学会外科专委会口腔颌面—头颈肿瘤内科协作组成立大会
江苏徐州
英文
86-88
2007-04-20（万方平台首次上网日期，不代表论文的发表时间）