A Combination Therapy of rAd-p53 with Chemotherapy for Advanced Oral Carcinoma by Selective Intraarterial Infusion
Purpose：To evaluate the safety and therapeutic effects of selective intraarterial rAd-p53 infusion combined with chemotherapy for advanced oral carcinoma．Methods：36patients with advanced SCC or ACC in oral region were subdivided into two groups．Allpatients underwent unilateral or bilateral retrograde selective catheterization of ECA．Through the arterial pumps，rAd-p53 combined with chemothereutic agents was administrated to group Ⅰ(7 patients)，rAd-p53 was administrated to group Ⅱ(6 patients)，andchemomereutic agents were administrated to group Ⅲ(10 patients)．Results：The complete response(CR)rate of group Ⅰ(28.57％) Was higher than that of groupⅡ (16.67％)and groupⅢ(10％).No replication-deficient virus Was detected in patients” serum，urine or sputum at any assay. Comparing with group Ⅲ，the clinical toxic syndromes and complications in the combination therapy group were significantly decreased vs．that of chemotherany group for both the number of cases and the extent(P<0.05)The transactivation of Bax and inactivation of Bcl-2 were only observed in group Ⅰ and Ⅱ．Conclusion：Routine chemotherapy combined with rAd-p53 infusion can increase the curative effect and decrease the toxic implication of cnemomerapy．
鳞状细胞癌 口腔癌 综合治疗 化学治疗
Li Long-Jiang Wang Li-Juan Li Yi Han Bo Huang Ju
Department of Oral and Maxillofacial Surgery,West China College of Stamotolog,Si chuan University,Ch West China Health Hospital,Sichuan University,Chengdu 610041，PR China
国内会议
第三次全国口腔颌面—头颈肿瘤综合治疗研讨会暨中华口腔医学会外科专委会口腔颌面—头颈肿瘤内科协作组成立大会
江苏徐州
英文
2-7
2007-04-20（万方平台首次上网日期，不代表论文的发表时间）