Anti-Human Immunodeficiency Virus Type 1 (HIV-1 IIIB) activity of lectins from marine invertebrates
We investigated five different specificity lectins from marine invertebrates. Four lectins, DTL and DTL-A from Didemnum. ternatanum, SVL-2 from Serpula. vermicularis. and CGL from Crenomytilys. grayanus were shown inhibition of infection of the C8166 cell line, by human immunodeficiency virus-1 IIIB in vitro. DTL, DTL-A and CGL displayed inhibition of cell-cell fusion syncytia formation between chronically infected H9 and uninfected C8166 cells. Cytotoxic activity was shown by DTL-A and CGL. In our studies, the lectins form marine invertebrates with different specificity were substantiated by an increase in the inhibitory activity in the series: DTL>SVL-2>DTL-A>CGL. SVL-1 didn” t display anti-HIV activity.
慢性感染 抗人类免疫缺陷病毒1型 凝集素 无脊椎动物 海洋动物 抗病毒活性 艾滋病
Wei Li Yuguang Du Valentina Molchanova Yong-Tang Zheng Irina Chikalovets Jian-Hua Wang Dong-Yun Ouyang Stanislav Kobelev Natalia Belogortseva Pavel Luk” yanov
Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,116023,China Pacific Institute of Bioorganic Chemistry,Far East Branch of the Russian Academy of Science,690022,V Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,650223,China
国内会议
全国首届海洋生物化学与分子生物学学术会议暨全国第五届海洋生命活性物质与天然生化药物学术研讨会
湖北宜昌
英文
558-564
2004-05-28（万方平台首次上网日期，不代表论文的发表时间）