Studies on antivirus effects of polysaccharides from Sargassum fusiforme in vitro
Objective: To assay antiviral effects of the polysaccharide and its separated products from Sargassum fusiforme on HSV-1 and CVB3 and their antiviral mechanism. Method: The antiviral effects of all samples on HSV-1 and CVB3 and their cytotoxicity on Vero cells were studied by CPE and MTT method. Antiviral mechanism of two samples was briefly studied by four different ways. Results: (c) The cytotoxicity of samples on vero cells was not detected (CC>5000?g/mL). (c) All samples except PSJ had obviously HSV-1 inhibitory effect. Antiviral activities of them were increasingly strengthened with raising their purities. Antiviral activities of F1, F2 and F4 were better than ACV. ? Antiviral activities of all samples on CVB3 were better than ribavirin injection. F1, F2 and F4 had remarkable anti-CVB3. (?) The experiment showed that polysaccharide not only able to kill the above viruses directly but also restrain them by getting into cell or absorbing on cells.
羊栖菜 多糖 单纯疱疹病毒 柯萨奇病毒 抗病毒药物
CEN Ying-zhou KHOO Gaik-ming WANG Ling-yun XU Shao-yu ZHANG Mei-ying WANG Yi-fei
Department of Chemistry,Faculty of Life Science and Technology,Jinan University,Guangzhou,Guangdong, Foshan Agrotechnical Station,Guangdong,China 528000 Guangzhou Jinan Biomedical Research and Development Center,Jinan University,Guangzhou,Guangdong,Chin
国内会议
全国首届海洋生物化学与分子生物学学术会议暨全国第五届海洋生命活性物质与天然生化药物学术研讨会
湖北宜昌
英文
283-288
2004-05-28（万方平台首次上网日期，不代表论文的发表时间）