Effects of CpG ODN on CD4+ and CD8+ T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine
CpG ODN is a noval immunostimulatory reagent. In this research,the effects ofimmunostimulatory CpG oligodeoxynucleotides(CpG ODN) on CD4+ and CD8+ T lymphocytessubpopulations in the newborn piglets blood were tested at different time with porcinereproductive and respiratory syndrome killed virus vaccine(PRRS vaccine) with or without CpGODN. The results suggested that,the CD4+/CD8+ ratio decreased with age in piglets inoculatedwith vaccine alone or GpC ODN with vaccine or phosphate buffer saline(PBS),however,it wasstable in piglets coinoculated with CpG ODN and PRRS vaccine(p>0.05),the use of CpG ODNcan prevent effectively the reduction of the proportion of CD4+ T lymphocytes. High titers of PRRS specific antibody can also be tested in the newborn piglets serum immunized PRRS vaccineand CpG ODN(p<0.05).
猪繁殖呼吸综合征 T细胞亚群 免疫反应 疫苗接种
Zhang Ling-hua
College of Life Sciences,South China Agricultural University,Guangzhou 510642,China
国内会议
广州
英文
804-814
2008-11-01（万方平台首次上网日期，不代表论文的发表时间）