Protective Effects of Aminoguanidin on Myocardial Mitochondrial No and Sulfhydryl Metabolism in Goats with Endotoxemia
To explore the role of NO and sulfhydryl on pathogenesis of endotoxemia in goats,48 goats were divided randomly into 4 groups of A,B,C and D with 12 goats in each group.Group A was normal control ；Group B was LPS group； Group C was LPS+AG group； Group Dwas AG group, each of groups is divided into 3h Slaughter group after the injection of LPS and6h group After injection of LPS. the changes of the content of MDA,total sulfhydryl(T-SH),protein SH(PB-SH) and non-protein SH(NP-SH) and the activity of nitric oxide synthase(TNOS),inducible nitric oxide synthase(iNOS)and nitric oxide(NO)level in myocardialmitochondria were Detected. The results showed that when the goat endotoxemia the content oftotal sulfhydryl,protein SH,non-protein SH in myocardial mitochondrial decreased,the content ofMDA and the activity of nitric oxide synthase,inducible Nitric oxide synthase and nitric oxidelevel in myocardial mitochondrial significantly increased. compared with the Lps group thesituation of aminoguanidine treatment group was significantly improved. The results indicatedthat,lipid peroxidation damage in the goat caused by the over-produced NO played an importantrole in the pathogenesis of endotoxemia. Aminoguanidine can effectivly antagonism lipidperoxidation damage.
山羊 内毒素血症 心肌线粒体 一氧化氮合酶 氨基胍 保护作用
Liu Zhao-ming Wu Cai-xia Yang Hong Guo Jian-ying Liu Jing Shi Da-you Li Ying Pan Jia-qiang Tang Zhao-xin
College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China
国内会议
广州
英文
790-803
2008-11-01（万方平台首次上网日期，不代表论文的发表时间）